The Role of Sirtuins in Health, Aging, and Metabolic Health

How Sirtuins Support Metabolic Health

In the pursuit of optimal health and longevity, the scientific community has increasingly turned its focus towards sirtuins – a family of proteins that play crucial roles in regulating cellular processes. Understanding sirtuins and their connection to health, and metabolic function offers profound insights into how we can support our bodies through natural solutions like Zooca® Calanus® Oil.

Sirtuin 1

What Are Sirtuins?

Sirtuins are a family of proteins known as modulators of metabolic pathways and cellular stress.  They possess enzymatic activity and are involved in deacetylation, a process that regulates the activity of other proteins by removing acetyl groups. There are seven known sirtuins in mammals (SIRT1-SIRT7), each playing distinct roles in cellular regulation. While SIRT1 is primarily localized in the cell nucleus, SIRT3 is found in the mitochondria

Why Are Sirtuins Important?

Sirtuins are pivotal in maintaining cellular health and function. Their role in metabolic regulation, stress response, and inflammation reduction makes them vital for overall well-being.

Increased activity of SIRT1 is found to attenuate insulin resistance and protect against fatty liver disease often seen among overweight and obese people. Low levels of SIRT1 are associated with inflammation and oxidative stress (Oberdoerffer et al. 2008). Sirtuins are also found to be associated to telomeres, although independently implicated in aging and disease. Previous studies in different model systems have demonstrated that both are tightly linked. SIRT1 and SIRT6 have also been shown to bind to telomeres and contribute to telomere integrity (Tennan & Chua 2010).

Key benefits include:

  • Improved Fat Metabolism: Sirtuins aid in lipid metabolism, promoting the utilization of fats for energy and preventing excessive fat accumulation.
  • Reduced Inflammation: By controlling inflammatory pathways, sirtuins help prevent chronic diseases associated with inflammation, such as cardiovascular diseases and neurodegenerative conditions.
  • Cellular Longevity: They support the maintenance of telomeres, and work as a protective cap on chromosomes, thus promoting cellular longevity.
Sirtuins_SIRT1_SIRT3

Linking Sirtuins to Zooca® Calanus® Oil

Zooca® Calanus® Oil, derived from the marine organism Calanus finmarchicus, is rich in omega-3 fatty acids in addition to several other marine fatty acids, marine policosanols, and the potent antioxidant astaxanthin.

Research with Zooca® Calanus® Oil has shown that this unique composition, in combination with exercise can positively influence the activity of sirtuins, thereby enhancing metabolic health and promoting healthy aging.

Lifestyle changes as regular physical training give a significant increase in the activities of SIRT1 and SIRT3 demonstrating that exercise alone can enhance the activity of sirtuins. When combining exercise with intake of 2 g/d with Zooca® Calanus® Oil, the responses in SIRT1 and SIRT3 were more pronounced than exercise alone or exercise plus nutritional guidance. This indicates that Zooca® Calanus® Oil may have a synergistic effect with exercise on sirtuin activation.

  • Activation of SIRT1 and SIRT3: Studies indicate that Zooca® Calanus® Oil can activate sirtuins, particularly SIRT1 and SIRT3, which are crucial for metabolic regulation and mitochondrial function. SIRT1 attenuates insulin resistance (IR) and enhances fat metabolism, while SIRT3 is essential for mitochondrial health and energy production.
  • Improved Metabolic Flexibility: By enhancing sirtuin activity, Zooca® Calanus® Oil supports the body's ability to switch between carbohydrate and fat metabolism, improving metabolic flexibility and efficiency.
  • Anti-Inflammatory Effects: The anti-inflammatory properties of Zooca® Calanus® Oil, partly mediated by its influence on sirtuins, may help reduce chronic inflammation, a key driver of aging and metabolic disorders.

Zooca® Calanus® Oil and Healthy Aging

Aging is characterized by a gradual decline in physiological functions. Common changes associated with aging include a decline in muscle mass and muscle functions, and redistribution of fat mass. These changes then contribute to metabolic disturbance and systemic pro-inflammatory states.

Intake of Zooca® Calanus® Oil in combination with lifestyle changes over a 4-month training intervention in elderly women improved the cardiovascular fitness by improved maximal cardiac output. This intervention also changed the body phenotype toward a lower abdominal fat mass and higher lean mass in general, as well as enhanced positive effect on leg muscle strength. These findings together suggest a higher muscular anabolic potential and strength/function of exercise with a accompanying use of Zooca® Calanus® Oil.

The synergy between Zooca® Calanus® Oil with mild lifestyle changes through exercise and training, positions our product as a powerful ally in promoting healthy aging. By supporting sirtuin activity, Zooca® Calanus® Oil may help to:

  • Increase muscle mass and strength: Mitigating chronic inflammatory responses that contribute to aging and sarcopenia.
  • Support Longevity: Contributing to an extended health span with improved quality of life.
Sirtuins

Summing up

Sirtuins play a critical role in maintaining health, regulating metabolism, and promoting longevity. Zooca® Calanus® Oil in combination with lifestyle changes, supports the activation and function of sirtuins, offering significant benefits through cardiovascular fitness and improved muscle mass and strength. By marketing Zooca® Calanus® Oil, your company can tap into the growing demand for products that support well-being and longevity by leveraging the science behind sirtuins.

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References

  1.  Dadova, K., Petr, M., Šteffl, M., Sontakova, L., Chlumsky, M., Matouš, M., & Šiklova, M. (2020). Effect of Calanus Oil Supplementation and 16 Week Exercise Program on Selected Fitness Parameters in Older Women. Nutrients, 12(2), 481. doi:10.3390/nu12020481
  2.  Štěpán, M., Daďová, K., Matouš, M., Krauzová, E., Sontáková, L., Koc, M., Larsen, T., Kuda, O., Štich, V., Rossmeislová, L., & Šiklová, M. (2022). Exercise Training Combined with Calanus Oil Supplementation Improves the Central Cardiodynamic Function in Older Women. Nutrients, 14(1), 149. doi:10.3390/nu14010149
  3. Cizkova, T., Štěpán, M., Daďová, K., Ondrůjová, B., Sontáková, L., Krauzová, E., & Šiklová, M. (2020). Exercise Training Reduces Inflammation of Adipose Tissue in the Elderly: Cross-Sectional and Randomized Interventional Trial. Journal of Clinical Endocrinology & Metabolism, 105(12), e4510. doi:10.1210/clinem/dgaa630
  4. Brezinova, M., Cajka, T., Oseeva, M., Štěpán, M., Daďová, K., Rossmeislová, L., Matous, M., Siklova, M., Rossmeisl, M., & Kuda, O. (2020). Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1865(2), 158576. doi:10.1016/j.bbalip.2019.158576
  5. Burhop, M., Schuchardt, J.P., Nebl, J., Muller, M., Lichtinghagen, R., & Hahn, A. (2022). Marine Oil from C. finmarchicus Enhances Glucose Homeostasis and Liver Insulin Resistance in Obese Prediabetic Individuals. Nutrients, 14(2), 396. doi:10.3390/nu14020396
  6. Wasserfurth, P., Nebl, J., Schuchardt, J.P., Müller, M., Böslau, T.K., Krüger, K., & Hahn, A. (2020). Effects of Exercise Combined with a Healthy Diet or Calanus finmarchicus Oil Supplementation on Body Composition and Metabolic Markers—A Pilot Study. Nutrients, 12(7), 2139. doi:10.3390/nu12072139
  7. Wasserfurth, P., Nebl, J., Rühling, M.R., Shammas, H., Bednarczyk, J., Koehler, K., Böslau, T.K., Krüger, K., Hahn, A., & Das, A.M. (2021). Impact of Dietary Modifications on Plasma Sirtuins 1, 3 and 5 in Older Overweight Individuals Undergoing 12-Weeks of Circuit Training. Nutrients, 13(11), 3824. doi:10.3390/nu13113824
  8. Oberdoerffer P, Michan S, Mcvay M, Mosttoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, ScullyY R, Prolla TA, Alt FW & Sinclair DA 2008. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell, 135, 907–18. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ruth I. Tennen1,2 ∙ Katrin F. Chua (2011) Chromatin regulation and genome maintenance by mammalian SIRT6  DOI:  10.1016/j.tibs.2010.07.009
  10.  Hisayuki Amano 1,2, Arindam Chaudhury 1, Cristian Rodriguez-Aguayo 3, Lan Lu 4, Viktor Akhanov 2, Andre Catic 2, Yury V Popov 5, Eric Verdin 6, Hannah Johnson 7, Fabio Stossi 7, David A Sinclair 8, Eiko Nakamaru-Ogiso 9, Gabriel Lopez-Berestein 3, Jeffrey T Chang 10, Joel R Neilson 1, Alan Meeker 11, Milton Finegold 12, Joseph A Baur 13, Ergun Sahin 1,2, (2019) Telomere dysfunction induces sirtuin repression that drives telomere-dependent disease. Cell Metab. 2019 29(6):1274–1290.e9. doi: 10.1016/j.cmet.2019.03.001
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